Chitinase-3-Like Protein 1 (CHI3L1): A Multifaceted Biomarker in Inflammation, Cancer, and Tissue Remodeling
Endocrinology Diagnostics
CHI3L1 Summary:
Molecular Characteristics:
- Glycoprotein in chitinase-like protein family
- Lacks enzymatic activity
- Conserved (β/α) 8 barrel structure
- Regulated by inflammatory mediators
Cellular Functions:
- Cell signaling receptor interaction
- Triggers MAP kinase, PI3K/AKT pathways
- Supports cell survival and movement
- Regulates matrix production
- Influences collagen formation
Inflammatory Roles:
- Immune response regulation
- Macrophage development control
- Increases in conditions like:
- Arthritis
- Inflammatory bowel disease
- Asthma
- Tissue repair and healing promotion
Cancer Biology Involvement:
- Elevated in multiple cancer types
- Promotes tumor angiogenesis
- Supports cancer cell invasion
- Facilitates metastasis
- Influences epithelial-mesenchymal transition
Key Signaling Pathways:
- Activated by IL-6, IL-1β, TNF-α
- Engages NF-κB and STAT3 pathways
Potential Therapeutic Target:
- Promising for inflammatory disorder treatments
- Potential cancer intervention strategy
Suitable ELISA Kits
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