Sphingosine 1-Phosphate: A Critical Mediator in Cell Signalling and Therapeutic Applications
Endocrinology Diagnostics
S1P Summary:
Molecular Characteristics:
- Bioactive sphingolipid metabolite
- Phosphorylated sphingosine
- Synthesized by sphingosine kinases
Receptor Signalling:
- 5 G-protein coupled receptors (S1P1-S1P5)
- Triggers multiple cellular pathways
- Regulates cell survival, proliferation
Physiological Functions:
- Immune cell trafficking
- Endothelial barrier maintenance
- Vascular tone regulation
- Angiogenesis control
- Cardiac function modulation
Pathological Implications:
- Autoimmune disorders
- Cancer progression
- Cardiovascular diseases
- Metastasis
- Treatment resistance
Therapeutic Potential:
- Fingolimod (multiple sclerosis treatment)
- Targeting approaches:
- Receptor modulators
- Enzyme inhibitors
- Antibody-based strategies
Clinical Research Focus:
- Autoimmune conditions
- Cancer therapy
- Fibrotic diseases
- Inflammatory disorders
Key Mechanism: Balances cell survival through sphingolipid rheostat, influencing proliferation and apoptosis.
Suitable ELISA Kits
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