TRACP-5b: An In depth look at the special biomarker for osteoclasts in bone health
Endocrinology Diagnostics
TRACP-5b is a unique metalloenzyme acid phosphatase specifically produced by osteoclasts in bone metabolism. Key characteristics include:
Biochemical Properties:
- Encoded by ACP5 gene
- Contains two iron atoms in its active site
- Optimum activity at pH 5.5-6.0
- Specifically found in osteoclasts
Functions:
- Facilitates bone resorption
- Breaks down bone matrix proteins
- Removes groups from bone sialoprotein
- Potentially involved in immune system regulation
Clinical Applications:
- Biomarker for bone metabolism conditions
- Monitors osteoporosis treatment effectiveness
- Detects bone metastasis in cancers
- Aids diagnosis of Paget's disease
- Indicates bone erosion in arthritis
Advantages as a Biomarker:
- Highly precise measurement of osteoclast function
- Stable at room temperature
- Consistent day-to-day variations
- Not affected by food consumption
- Provides reliable results in patients with kidney dysfunction
Suitable ELISA Kits
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